What Is
PDRN?
The Short Answer.
PDRN — Polydeoxyribonucleotide — is a DNA fragment derived from nucleotides that signals skin cells to repair, renew, and regenerate. Think of it as handing your skin a set of biological instructions: repair, rebuild, renew.
Originally developed for clinical aesthetic medicine — administered via injections — PDRN has been adapted for topical skincare through advances in low molecular weight formulation. The result is all the cellular renewal power of a clinical treatment delivered through your daily serum.
Rejuvea HA's PDRN formulations use 100% vegan INJIN PDRN, sourced from Artemisia capillaris — a resilient healing plant. No salmon. No ethical compromise. Clinically proven to outperform animal-derived alternatives in fibroblast proliferation and collagen stimulation studies.
What PDRN Does for Your Skin.
Four clinically grounded benefits that make PDRN the most complete renewal ingredient in modern skincare.
Skin Cell Renewal
PDRN activates the skin's natural regeneration cycle at a cellular level. By stimulating fibroblast proliferation and triggering biological repair pathways, it drives the turnover of damaged cells and the production of fresh, healthy ones — resulting in visibly smoother texture and a genuinely renewed complexion.
Boosts Collagen & HA
PDRN stimulates the skin to produce its own collagen and hyaluronic acid — not by applying these ingredients on top, but by triggering the biological mechanisms that synthesise them internally. Clinical data shows a 25–35% increase in collagen synthesis over 8–12 weeks and a 45% improvement in hydration after just 4 weeks.
Instant Glass Skin Glow
Results begin from the very first use. The emollient-rich formula delivers an immediate glass-skin effect — skin looks luminous, bouncy, and lit-from-within. This dual action of instant cosmetic glow combined with longer-term cellular renewal is what makes PDRN an exceptional addition to any regimen.
Safe for All Skin Types
Vegan PDRN carries a low irritation profile and is well-tolerated across every skin type. Safe during pregnancy and breastfeeding, fragrance-free, and fully compatible with retinol, Vitamin C, AHAs/BHAs, and exosome serums. Use morning and evening from day one — no purging period, no photosensitivity.
Three Types.
One Clear Choice.
Animal-Derived
Historically extracted from salmon sperm DNA. Effective in clinical settings but raises ethical and sustainability concerns for many consumers.
Vegan PDRN
Derived from plant sources such as Artemisia capillaris. Clinically proven to match or outperform animal alternatives, with a lower irritation profile and a significantly reduced environmental footprint.
INJIN Vegan PDRN
The patented vegan PDRN ingredient used in Rejuvea HA formulations. Backed by independent clinical data confirming it outperforms both animal-derived and other vegan alternatives in fibroblast proliferation and collagen stimulation studies.*
How to Use PDRN
AM & PM.
- 1Cleanse with a gentle cleanser
- 2Apply one pump of PDRN Serum to face and neck
- 3Follow with moisturizer
- 4Finish with SPF 30+
The 18% emollient blend creates an immediate glass-skin glow — the perfect luminous base for SPF and makeup.
- 1Double cleanse to remove makeup and SPF
- 2Apply one pump of PDRN Serum to face and neck
- 3Follow with moisturizer or night cream
- 4Optional: layer Exosome Serum underneath for amplified renewal
PDRN activates regeneration pathways most active during sleep — supporting the skin's own nightly repair window.
One serum, every skin type.
Deep cellular renewal + stimulates the skin's own HA production for durable, inside-out hydration.
Lightweight, non-comedogenic formula; improves texture and bounce without heaviness or congestion.
Vegan INJIN PDRN has a low irritation profile — patch test recommended before full use.
Addresses texture, bounce, and dullness uniformly across all zones of the face.
Stimulates collagen and HA production to visibly restore volume, smooth fine lines, and firm skin structure.